You are here: Home / People / Mitchell M. Holland
Mitchell M. Holland

Mitchell M. Holland

Main Content

  • Associate Professor, Biochemistry & Molecular Biology
014 Thomas Building
University Park, Pa 16802
Email: mmh20@psu.edu
Phone: (814) 865-5286

Education

  1. Postdoctoral Fellow, The Johns Hopkins University School of Medicine, Department of Pediatrics, Baltimore, Maryland. 1990
  2. Ph.D. in Biochemistry, The University of Maryland, College Park, Maryland. 1989
  3. Mentor: John A. Gerlt, Currently a Professor of Biochemistry, Gutgsell Chair, Professor of Chemistry, and Professor of Biophysics and Computational Biology, School of Molecular and Cellular Biology, University of Illinois.
  4. B.S. in Chemistry, Hobart College, Geneva, New York. 1984

Biography

Dr. Holland holds a Bachelor of Science in Chemistry with a minor in Philosophy from Hobart Collage in Geneva, New York (1984). He earned his Ph.D. in Biochemistry at the University of Maryland College Park (1989) and was a Postdoctoral Fellow at the Johns Hopkins University School of Medicine in Baltimore, Maryland where he studied Human Genetics (1990).

Dr. Holland is a Fellow in the American Academy of Forensic Sciences, has served as an associate professorial lecturer in the Forensic Science Department at the George Washington University, and has been an adjunct faculty member at other colleges and universities. Dr. Holland has been on the Editorial Board of the Journal of Forensic Sciences and a member of the Advisory Board of the International Journal of Legal Medicine. He has held positions on governmental and company advisory boards (e.g., DMORT and Identigene Inc), and has been recognized by organizations for his work (e.g., by the FBI and NY City OCME).

Prior to being asked to help develop the Forensic Science program at Penn State, Dr. Holland was the Senior Vice President, Operations and Laboratory Director of The Bode Technology Group (Bode). Bode is one of the largest forensic DNA laboratories in the U.S., providing DNA identification services to public agencies and private citizens. Bode specializes in forensic casework, convicted offender databanking, forensic research, and product development. Dr. Holland oversaw the laboratory activities at Bode, as well as the IT, applied research, and wet-lab product development groups. Dr. Holland's laboratory at Bode was capable of producing greater than 30,000 forensic DNA profiles each month from sources such as convicted offender samples and victim family references. In addition, Dr. Holland's laboratory was capable of completing work on more than 800 forensic cases per month. Journal articles published by Dr. Holland while at Bode include;

    • Development of a quality, high throughput DNA analysis procedure for skeletal samples to assist with the identification of victims from the world trade center attacks, MM Holland, CA Cave, CA Holland, TW Bille (2003) Croatian Medical Journal, 44(3), pp. 264-72
    • Human hair histogenesis for the mitochondrial DNA forensic scientist, CA Linch, DA Whiting, MM Holland (2001) The Journal of Forensic Sciences, 46(4), pp. 844-53

 

From 1991-2000, Dr. Holland held various positions at the Armed Forces DNA Identification Laboratory (AFDIL) in Rockville, Md., including Scientific Laboratory Director from 1993-2000. At AFDIL, Dr. Holland was responsible for the laboratory that identified the remains of 1st Lt Michael Blassie (the Vietnam Unknown Soldier) and Tsar Nicholas Romanov. The focus of the work at AFDIL was the identification of U.S. military personnel killed in Vietnam, Korea, and as a result of conflicts during World War II. AFDIL continues to be responsible for the DNA identification of every U.S. military soldier killed while serving his/her country today. Journal articles published by Dr. Holland while at AFDIL include;

    • A sensitive denaturing gradient-gel electrophoresis assay reveals a high frequency of heteroplasmy in hypervariable region I of the human mtDNA control region, LA Tully, TJ Parsons, RJ Steighner, MM Holland, MA Marino, VL Prenger (2000) American Journal of Human Genetics, 67(2), pp. 432-43
    • Mitochondrial DNA sequence analysis validation and use for forensic casework, MM Holland, TJ Parsons (1999) Forensic Science Review, 11, pp. 21-50
    • Amplification and sequencing of Mitochondrial DNA in forensic casework, RJ Steighner and MM Holland (1998) Methods in Molecular Biology: Forensic DNA Profiling Protocols, 98, pp. 213-224
    • A high observed substitution rate in the human mitochondrial DNA control region, TJ Parsons, DS Muniec, K Sullivan, N Woodyatt, R Alliston-Greiner, MR Wilson, DL Berry, KA Holland, VW Weedn, P Gill, and MM Holland (1997) Nature Genetics, 15, pp. 363-368
    • Mitochondrial DNA sequence heteroplasmy in the Grand Duke of Russia Georgij Romanov establishes the authenticity of the remains of Tsar Nicholas II, PL Ivanov, MJ Wadhams, RK Roby, MM Holland, VW Weedn, and TJ Parsons (1996) Nature Genetics, 12, pp. 417-420
    • Establishing the identity of Anna Anderson Manahan, M Stoneking, T Melton, J Nott, S Barritt, R Roby, M Holland, V Weedn, P Gill, C Kimpton, R Aliston-Greiner, and K Sullivan (1995) Nature Genetics, 9(1), pp. 9-10

 

Dr. Holland has had extensive experience over the last 18 years with human remains identification cases, including the identification of victims from the World Trade Center disasters and from numerous commercial airline accidents.

Dr. Holland has given hundreds of lectures and/or presentations on forensic DNA analysis (many at professional conferences and seminars), and has published 40 peer reviewed journal articles, book chapters and other manuscripts. In addition, Dr. Holland has been qualified in numerous courts of law as an expert in forensic DNA analysis. Finally, Dr. Holland has established a consulting firm (www.forensicdnaconsultants.com) to support the legal, law enforcement and crime laboratory communities.

Employment

 

Professional Affiliations, Special Appointments, Testimony

  • American Academy of Forensic Sciences, Fellow

  • Member & Scientific Committee Member, International Society for Applied Biological Sciences, 2004-Present

  • Head, Module II, Masters of Forensic Science, University of Split, Split, Croatia, 2016-Present

  • American Society of Human Genetics, Previous Member

  • Advisory Board Member of the Fundacion de Anthropologia Forense de Gualemala (FAFG) forensic DNA laboratory located in Guatemala City, Guatemala, 2009-2010 

  • Member of the Scientific Working Group on DNA Analysis Methods (SWGDAM), FBI Academy, 1992-2000

  • Associate Professorial Lecturer in Forensic Sciences, Department of Forensic Sciences, George Washington University, Washington, DC, 1993-2000 (Course Number: Forensic DNA Profiling 254)

  • Adjunct Assistant Professor, Department of Obstetrics and Gynecology, University of Maryland at Baltimore, 1994-1999

  • Associate Graduate Faculty, Forensic Science Program, Marshall University Huntington, WV, 1997-1999

  • Editorial Board Member for the Journal of Forensic Sciences, 2000-2010

  • Advisory Board Member for the International Journal of Legal Medicine, 1996-2007

Other Editorial Activity:
  • American Journal of Human Genetics, Biotechniques, Croatian Medical Journal, Electrophoresis, Forensic Science International Genetics, Forensic Science Reviews National Institutes of Justice Grant Review Board, 1996, 1997, 1999, 2007

  • Testified:  More than 20 Times

Continuing Education & Workshops

  • Workshop Organizer, University of Split, Split, Croatia, “Complex STR Mixture Interpretation Workshop”, with a total of 15 attendees from a private company and the Police Laboratory from Zagreb, June 2015

 

  • Workshop Co-Organizers, MN BCA, St. Paul, MN, “Advancing Human Forensic DNA Analysis Using Next Generation Sequencing (NGS) Technology”, with a total of 32 attendees from the Tri-County Regional Forensic Laboratory (TCRFL), Anoka County Sheriff’s Office, in Andover, MN (North of Minneapolis-St. Paul, MN), the Hennepin County Sheriff’s Office (HCSO) Crime Laboratory (Minneapolis, MN), and the MN BCA Crime Laboratory (St. Paul, MN), June 2015

 

  • Session Organizer, 8th International Society for Applied Biological Sciences, Bi-Annual Meeting, Split, Croatia, session: “NextGen Sequencing for Human Identification”, June 2013

 

  • Workshop Organizer, Mid Atlantic Association of Forensic Scientists, Annual Meeting, Virginia Beach, VA, workshop: “DNA Mixture Interpretation”, May 2011

 

  • Workshop Organizer, 21st International Symposium on Human Identification, San Antonio, TX, workshop: “LCN STR Analysis”, October 2010

 

  • Co-Workshop Organizer, Mid Atlantic Association of Forensic Scientists, Annual Meeting, State College, PA, workshop: “DNA Mixture Interpretation”, May 2010

 

  • Co-Workshop Organizer, Penn State University, University Park, PA, workshop: “Forensic Science Workshop Series: From the Scene to the Classroom - Biology and Bioterrorism”, June 2009

 

  • Workshop Organizer, Study Abroad Program through Penn State University and the University of Zagreb, Zagreb and Split, Croatia, “LCN STR Analysis”, June 2008

 

  • Co-Workshop Organizer, The American Academy of Forensic Sciences, Chicago, IL, workshop: “Extracting DNA from Challenged Samples“, February 2003

 

  • Co-Workshop Organizer, the 10th International Symposium on Human Identification, Orlando, FL, workshop: “MtDNA Sequence Analysis in Forensic Casework: Methods and Current Issues”, September 1999

 

  • Co-Course Director, MtDNA Training Course (two weeks),GeorgeMasonUniversity, Prince William County Campus, The Institute for Biosciences, Bioinformatics, and Biotechnology,Manassas,VA, November 1998

 

  • Co-Workshop Organizer, the 2nd European Symposium on Human Identification, Innsbruck, Austria, workshop: “MtDNA Sequence Analysis in Forensic Casework: Methods and Current Issues”, June 1998

 

  • Co-Organizer, workshop: “The First International Workshop on Human Mitochondrial DNA”, Washington, DC, October 1997

 

  • Faculty Member, “The First European-American Intensive Course in PCR Based Clinical and Forensic Testing”, Split, Croatia, September 1997

 

  • Organized and Attended, “Statistical Genetics for Forensic Scientists”, by Bruce Weir, Rockville, MD, September 1997

 

  • Faculty Member, The American Academy of Forensic Sciences, New York, NY, workshop: "Advanced DNA Technologies: Automation and Application", February 1997

 

  • Faculty Member, The American Academy of Forensic Sciences, Nashville, TN, workshop: "Advanced DNA Technologies", February 1996

 

  • Faculty Member, The American Academy of Forensic Sciences, Seattle, WA, workshop: "Implementation and Consequences of New DNA Technologies: The Sequel", February 1995

 

  • Course Co-Director, The Armed Forces Institute of Pathology and The American Registry of Pathology, in conjunction with The Uniformed Services University of the Health Sciences, Bethesda, MD, "Methods and Advanced Techniques in Human Identification", June 1994

 

  • Faculty Member, The American Academy of Forensic Sciences, San Antonio, TX, workshop: "Implementation and Consequences of New DNA Technologies in the Forensic Laboratory", February 1994

 

  • Faculty Member, The Fourth International Symposium on Human Identification, Scottsdale, Arizona, workshop: "Practical Techniques in DNA Analysis of PCR Fragments", September 1993

 

  • Visiting Research Scientist, FBI Forensic Science Research and Training Center, The FBI Academy, Quantico, VA, September-December 1991

Selected Publications

  1. Rates of mtDNA Heteroplasmy in a European Population Group. JA McElhoe, MM Holland (2017) manuscript in preparation
  2. Recurrent mutations at positions 185 and 189 of the mitochondrial DNA control region show evidence of selection and age-related accumulation. MM Holland, JA McElhoe (2017) manuscript in preparation
  3. Massively parallel sequencing on highly fragmented DNA from human skeletal material. E Zavala, MM Holland (2017) manuscript in preparation
  4. Assessing heteroplasmic variant drift in the mtDNA control region of human hairs using an MPS approach. JM Gallimore, JA McElhoe, MM Holland (2017) manuscript submitted to Forensic Science International: Genetics
  5. Evaluation of GeneMarker® HTS for improved alignment of mtDNA MPS data, haplotype determination, and heteroplasmy assessment. MM Holland, E Pack, JA McElhoe (2017) Forensic Science International: Genetics, 28, pp. 90-98
  6. MPS analysis of the mtDNA hypervariable regions on the MiSeq with improved enrichment, MM Holland, LA Wilson, S Copeland, G Dimick, CA Holland, R Bever, JA McElhoe (2017) International Journal of Legal Medicine (http://link.springer.com/article/10.1007/s00414-017-1530-9)
  7. Considering DNA damage when interpreting mtDNA heteroplasmy in deep sequencing data, MM Rathbun, JA McElhoe, W Parson, MM Holland (2017) Forensic Science International: Genetics, 26, pp. 1-11
  8. A custom software solution for forensic mtDNA analysis of MiSeq data, M Holland, J McElhoe (2015) Forensic Science International: Genetics, Supplemental Series 5, pp. e614-e16
  9. Cultural inter-population differences do not reflect biological distances: an example of interdisciplinary analysis of populations from Eastern Adriatic coast, Z Basic, AR Fox, I Anteric, I Jerkovic, O Polasek, S Andelinovic, MM Holland, D Primorac (2015) Croatian Medical Journal, 56, pp. 230-238
  10. Evaluation of the RapidHIT™ 200, an automated human identification system for STR analysis of single source samples, M Holland, F Wendt (2015) Forensic Science International: Genetics, 14, pp. 76-85
  11. Maternal age effect and severe germline bottleneck in the inheritance of human mitochondrial DNA, B Rebolledo-Jaramillo, MSW Su, N Stoler, JA McElhoe, B Dickins, D Blankenberg, T Korneliussen, F Chiaromonte, R Nielsen, MM Holland, IM Paul, A Nekrutenko, and KD Makova (2014) Proceedings of the National Academy of Sciences, 11, pp. 15474-15479
  12. Development and assessment of an optimized next-generation DNA sequencing approach for the mtgenome using the Illumina MiSeq. J McElhoe, M Holland, K Makova, MS-W Su, I Paul, C Baker, S Faith, B Young (2014) Forensic Science International: Genetics, 13, pp. 20-29
  13. Forensic mitochondrial DNA analysis: current practices and future potential. M Holland, T Melton, C Holland (2013) Forensic DNA Analysis, Current Practices and Emerging Technologies; CRC Press, Editor Jaiprakash G. Shewale and Co-Editor Ray H. Liu, pp. 249-278
  14. A cautionary note on switching mitochondrial DNA reference sequence in forensic genetics. A Salas, M Coble, S Desmyter, T Grzbowski, L Gusmão, C Hohoff, MM Holland, et al. (2012) Forensic Science International: Genetics, 6, pp. e182-184
  15. Molecular analysis of the human mitochondrial DNA control region for forensic identity testing. MM Holland (2012) Curr Protoc Hum Genet, Chapter 14:Unit 14.7
  16. Forensic mitochondrial DNA analysis: current practices and future potentials. T Melton, C Holland, M Holland (2012) Forensic Science Review, 24, pp. 101-122
  17. Second generation sequencing allows for mtDNA mixture deconvolution and high resolution detection of heteroplasmy. MM Holland, M McQuillan, KA O’Hanlon (2011) Croatian Medical Journal, 52, pp. 299-313
  18. GeneMarker® HID: a reliable software tool for the analysis of forensic STR data. M Holland, W Parson (2011) The Journal of Forensic Sciences, 56(1), pp. 29-35
  19. Development of a quality, high throughput DNA analysis procedure for skeletal samples to assist with the identification of victims from the world trade center attacks. MM Holland, CA Cave, CA Holland, TW Bille (2003) Croatian Medical Journal, 44(3), pp. 264-272
  20. A new database of mitochondrial DNA hypervariable region 1 and 2 sequences from 162 Japanese individuals. K Imaizumi, TJ Parsons, M Yoshihno, MM Holland (2002) International Journal of Legal Medicine, 116 (2), pp. 68-73
  21. Improved mtDNA sequence analysis of forensic remains using a “mini-primer set” amplification strategy. MN Gabriel, EF Huffine, JH Ryan, MM Holland, TJ Parsons (2001) The Journal of Forensic Sciences, 46(2), pp. 247-253
  22. Human hair histogenesis for the mitochondrial DNA forensic scientist. CA Linch, DA Whiting, MM Holland (2001) The Journal of Forensic Sciences, 46(4), pp. 844-853
  23. Multiplex PCR amplification of eight STR loci in Austrian and Croatian Caucasian populations. J Ross, W Parson, I Furac, M Kubat, M Holland (2001) International Journal of Legal Medicine, 115, pp. 57-60
  24. Molecular analysis of the human mitochondrial DNA control region for forensic identity testing. MM Holland, EF Huffine (2001) Curr Protoc Hum Genet, Chapter 14:Unit 14.7
  25. A sensitive denaturing gradient-gel electrophoresis assay reveals a high frequency of heteroplasmy in hypervariable region I of the human mtDNA control region. LA Tully, TJ Parsons, RJ Steighner, MM Holland, MA Marino, VL Prenger (2000) American Journal of Human Genetics, 67(2), pp. 432-443
  26. DNA Commission of the International Society for Forensic Genetics: guidelines for mitochondrial DNA typing. A Carracedo, W Bar, P Lincoln, W Mayr, N Morling, B Olaisen, P Schneider, B Budowle, B Brinkmann, P Gill, M Holland, G Tully, M Wilson (2000) Forensic Science International, 110(2), pp. 79-85
  27. Mitochondrial DNA sequence analysis – validation and use for forensic casework. MM Holland, TJ Parsons (1999) Forensic Science Review, 11, pp. 21-50
  28. Comparative identity and homogeneity testing of the mtDNA HV1 region using denaturing gradient gel electrophoresis. RJ Steighner, LA Tully,  JD Karjala, MD Coble, MM Holland (1999) Journal of Forensic Sciences, 44(6), pp. 1186-1198
  29. Expanding the forensic German Mitochondrial DNA control region database: genetic diversity as a function of sample size and microgeography. H Pfeiffer, B Brinkmann, J Hühne, B Rolf, AA Morris, R Steighner, MM Holland, P Forster (1999) International Journal of Legal Medicine, 112, pp. 291-298
  30. The use of DNA analysis in the identification and re-association of remains recovered from TWA Flight 800 and KAL Flight 801. DA Lee, JM Willard, JP Ross, DE Katz, MM Holland (1999) The 6th Indo Pacific Congress on Legal Medicine and Forensic Sciences, INPALMS-1998-KOBE, Yoshitsugu Tatsuno (ed.), pp. 249-252
  31. A validation study for the extraction and analysis of DNA from human nail material and its application to forensic casework. TD Anderson, JP Ross, DA Lee, RK Roby, JJ Canik, MM Holland (1999) Journal of Forensic Sciences, 44(5), pp.1053-1056
  32. Mitochondrial DNA regions HVI and HVII population data. B Budowle, MR Wilson, JA DiZinno, C Stauffer, MA Fasano, MM Holland, KL Monson (1999) Forensic Science International, 103, pp. 23-35
  33. Mitochondrial DNA extraction and typing from isolated dentin – experimental evaluation in a Korean population. H Pfeiffer, R Steighner, R. Fisher, H Mörnstad, C-L Yoon, and MM Holland (1998) Intern Journal of Legal Med, 111, pp. 309-313
  34. Population data for 101 Austrian Caucasian mitochondrial D-Loop sequences: application of MtDNA sequence analysis to a forensic case. W Parson, TJ Parsons, R Scheithauer, and MM Holland (1998) The International Journal of Legal Medicine, 111, pp. 124-132
  35. Recovery of DNA for PCR amplification from blood and forensic samples using a chelating resin. JM Willard, DA Lee, and MM Holland (1998) Methods in Molecular Biology: Forensic DNA Profiling Protocols, 98, pp. 9-18
  36. Amplification and sequencing of Mitochondrial DNA in forensic casework. RJ Steighner and MM Holland (1998) Methods in Molecular Biology: Forensic DNA Profiling Protocols, 98, pp. 213-224
  37. A high observed substitution rate in the human mitochondrial DNA control region. TJ Parsons, DS Muniec, K Sullivan, N Woodyatt, R Alliston-Greiner, MR Wilson, DL Berry, KA Holland, VW Weedn, P Gill, and MM Holland (1997) Nature Genetics, 15, pp. 363-368
  38. Multiplex systems for the amplification of short tandem repeat loci:  evaluation of laser fluorescence detection. MD Ricciardone, AM Lins, JW Schumm, and MM Holland (1997) Biotechniques, 23, pp. 742-747
  39. DNA analysis. VW Weedn, DA Lee, RK Roby, MM Holland (1997) Analytical Therapeutic Drug Monitoring and Toxicology, SHY Wong and I Sunshine (eds.), CRC Press, pp. 35-50
  40. Mitochondrial DNA sequence heteroplasmy in the Grand Duke of Russia Georgij Romanov establishes the authenticity of the remains of Tsar Nicholas II.  PL Ivanov, MJ Wadhams, RK Roby, MM Holland, VW Weedn, and TJ Parsons (1996) Nature Genetics, 12, pp. 417-420
  41. Establishing the identity of Anna Anderson Manahan. M Stoneking, T Melton, J Nott, S Barritt, R Roby, M Holland, V Weedn, P Gill, C Kimpton, R Aliston-Greiner, and K Sullivan (1995) Nature Genetics, 9(1), pp. 9-10
  42. DNA and the forensic odontologist. BC Smith, MM Holland, DL Sweet, JA DiZinno (1995) The Manual of Forensic Odontology, American Society of Forensic Odontology, CM Bowers and GL Bell (eds.), pp. 283-298
  43. Serological and DNA methods for the identification of urine specimen donors. MM Holland, R Roy, and MD Fraser (1995) The Handbook of Workplace Drug Testing, RH Liu and BA Goldberger (eds.), pp. 159-180
  44.  Further validation of the Quad 1 STR DNA typing system: a collaborative effort to identify victims of a mass disaster. TM Clayton, DL Fisher, MM Holland, DA Lee, CN Maguire, VW Weedn, JP Whitaker, and P Gill (1995) Forensic Science International, 76, pp. 17-25
  45. Mitochondrial DNA sequence analysis of human remains. MM Holland, DL Fisher, RK Roby, J Ruderman, C Bryson, and VW Weedn (1995) Crime Laboratory Digest, 22(4), pp. 3-8
  46. Identification of human remains using mitochondrial DNA sequencing: potential mother-child mutational events. MM Holland, RK Roby, DL Fisher, J Ruderman, DA Lee, CK Bryson, T Kupferschmid, RS Loft, AJ Eisenberg (1994) Advances in Forensic Haemogenetics, W Bär, A Fiori and U Rossi (eds.), pp. 399-406
  47. Typing human DNA using capillary electrophoresis: comparison of slab gel and capillary formats. MM Holland, LA Turni, S Delrio, M Marino, RS Lofts, DL Fisher, J Ross, JW Schumm, and PL Williams (1994) Advances in Forensic Haemogenetics, W Bär, A Fiori and U Rossi (eds.), pp. 156-159
  48. Mitochondrial DNA sequence analysis of human skeletal remains: identification of remains from the Vietnam War. MM Holland, DL Fisher, LG Mitchell, WC Rodriguez, JJ Canik, CR Merril, and VW Weedn (1993) The Journal of Forensic Sciences, 38(3), pp. 542-553
  49. Extraction, evaluation, and amplification of DNA from decalcified and undecalcified United States Civil War bone. DL Fisher, MM Holland, L Mitchell, PS Sledzik, AW Wilcox, M Wadhams, and VW Weedn (1993) The Journal of Forensic Sciences, 38(1), pp. 60-68
  50. A systematic approach to the sampling of dental DNA. BS Smith, VW Weedn, GR Warnock, and MM Holland (1993) The Journal of Forensic Sciences (Technical Note), 38(5), pp. 1194-1209
  51. Guidelines for the use of mitochondrial DNA sequencing in forensic science, MR Wilson. MM Holland, M Stoneking, JA DiZinno, and B Budowle (1993) Crime Laboratory Digest, 20(4), pp. 68-77
  52.  Short tandem repeat loci: application to forensic and human remains identification. MM Holland, DL Fisher, DA Lee, CK Bryson, and VW Weedn (1993) The Second International Conference on DNA Fingerprinting, DNA Fingerprinting: State of the Science, SDJ Pena, R Chakraborty, JT Epplen, and AJ Jeffreys (eds.), pp. 267-274
  53. Application of serological and DNA methods for identification of urine specimen donors. MM Holland, R Roy, MD Fraser, and RH Liu (1993) Forensic Science Review, 5(1), pp. 1-14
  54. Programmed demethylation in CpG islands during human fetal development. BR Migeon, MM Holland, DJ Driscoll, and JC Robinson (1991) Somatic Cell and Molecular Genetics, 17(2), 159-168
  55. Isolation and characterization of a small catalytic domain released from the Adenylate Cyclase from Escherichia coli by digestion with trypsin. MM Holland, TK Leib, and JA Gerlt (1988) The Journal of Biological Chemistry, 263, 14661-14668

Honors and Awards

  • Analytical Chemistry Prize, Hobart College 1983
  • Ralph Hadley Bullard Prize for Achievement in Chemistry, Hobart College 1984
  • 10 Years of Excellence in DNA, The FBI Laboratory 1998
  • Distinguished Service Award, Armed Forces Institute of Pathology 2000
  • Award of Appreciation, Detectives' Endowment Association , NYPD 2001
  • Award of Appreciation, Office of the Chief Medical Examiner, NYC 2003
  • Presidential Citation, Hobart & William Smith Colleges 2006
  • Award of Merit, American Academy of Forensic Sciences 2010