Introduction to Research - Dr. Holland
Dr. Holland’s research group is focused on advancing forensic DNA applications. Much of his research involves basic biological discovery, especially in the area of mitochondrial (mt) DNA genetics. The group is currently leveraging the power of massively parallel sequencing (MPS) to measure rates of mtDNA heteroplasmy in different population groups; evaluate the transmission of heteroplasmic variants between maternal relatives and tissue types; assess the impact of damage on the interpretation of low-level heteroplasmic variants; and develop best practices for the application of MPS approaches in forensic casework. In addition, members of Dr. Holland’s group are exploring ways to extract small fragments of DNA from highly degraded skeletal material for single nucleotide polymorphism (SNP) analysis on an MPS platform.
Find out more information about Dr. Holland and his research group website.